Liver metabolism goes to pot

Journal of Clinical Investigation – Liver metabolism goes to pot

Endocannabinoids are natural cannabis-like proteins that can stimulate appetite and regulate fat metabolism by binding to receptors called CB1. Drugs that block these receptors may be useful for treating obesity by suppressing appetite and food intake.

In a new study appearing in the May 2 print issue of The Journal of Clinical Investigation, George Kunos and colleagues from the NIH examine the possible role of the liver as a target of the metabolic actions of endocannabinoids.

The authors find that liver cells express CB1 and when stimulated, these cells activate a signaling pathway that ultimately increases fatty acid synthesis. The cellular proteins that are activated in the liver upon CB1 stimulation are the same as those known to be activated in the brain and thus may be a common molecular target for metabolic regulation and appetite control.
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Oh Dear, this is just another example of the research into the holistic relationship humans have with cannabis that the unprincipled family value ning nongs – United Future Outdoor – would rather be suppressed.  UFO’s were prepared to roll government on confidence and supply (the right to write a cheque out on treasury) rather than admit its prohibitory fetish over cannabis is a corruption of harm minimisation and social equity in  ‘public health’. If not perverse, what for heavens name is?  /Blair

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